Hemlock Hoax thinks he can "put it all over" Sherlock Holmes, and his sleuthing is somewhat of a joke in the little tropical town where he lives.

Nell, the boss's daughter, uses Sherlock Holmes' detective work, to choose between the two suitors at her dad's broker's office.

Little Sherlock Holmes, Jr., reads the doughty doings of his hero-god, and at once determines to become a detective himself.

Chief of Police Ivorytop and Chief of Detectives Sherlock Bonehead, of Rottenport, fall in love with Helen, a girl from the city

The master crook steals the sweetheart of Sherlock, a great detective. Sherlock undertakes to recover her.

Sherlocko and Watso, the world-famous detectives, are quietly ensconced in their office when suddenly there bursts in on their cogitations a railroad official. He is evidently in great distress, and we soon discover its cause. He has met with a loss, a daring robbery has occurred at his station.

When a bored Sherlock eagerly takes the case of Gabrielle Valladon following an attempt on her life, the search for her missing husband leads to Loch Ness and the legendary monster.

A burglar enters the home of a wealthy man and steals a valuable necklace. A reward of $500 is offered for the thief's apprehension. A couple of rube detectives start out to find the robber and succeed in taking into custody the victim of the robbery and the real detective who is on the case.

Tom and Jerry need to learn to work together in order to help Sherlock Holmes with an investigation of a jewel theft. But still, they are cat and mouse!